The present studies investigated relationships between the Big Five factors of personality and reactions to everyday social interactions. One study was conducted in the US, the other was conducted in Germany. In both studies, undergraduate students completed the Big Five Inventory (BFI) and recorded all social interactions of at least 10 minutes duration over a two-week period. In the US sample, Extraversion was positively related to enjoyment and intimacy of social interactions as well as participants feeling liked and respected. In contrast, no such relationships were found in the German sample. In both samples Agreeableness was positively related to enjoyment of interactions and feeling liked and respected. In both samples, there was a positive relationship between Conscientiousness and feeling respected. In the German sample, there were positive relationships between Conscientiousness and enjoyment and intimacy of social interactions, whereas there were no such relationships in the US sample. Neuroticism was negatively related to feeling liked in the US sample, but no further effects were found in neither sample. For the US sample, there were positive relationships between Openness and all ratings of interactions, whereas in the German sample, Openness was not related to any outcomes.